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抑制剂/激活剂

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凋亡与自噬

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Brefeldin A BFA; Cyanein; Decumbin

BFA; Cyanein; Decumbin

货号：
TK0116
规格：

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	20350-15-6
生物活性	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.
分子式	C16H24O4
分子量	280.36
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (356.68 mM; Need ultrasonic) Ethanol : 33.33 mg/mL (118.88 mM; Need ultrasonic)
体外研究	Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT and actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A and ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38 HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D and 2D cultures and inhibits the migration and MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231.
文献	•Cancer Res. 2020 Sep 15;80(18):3892-3905. •Theranostics. 2021 Jun 1;11(15):7491-7506. •Cancer Lett. 2021 Jun 18. •Cell Death Dis. 2020 Nov 11;11(11):969. •Cell Death Dis. 2018 Nov 16;9(12):1143. •NPJ Breast Cancer. 2022 Jan 10;8(1):2. •PLoS Pathog. 2020 Oct 19;16(10):e1008947. •J Autoimmun. 2019 May;99:39-47. •Int J Nanomedicine. 2018 Jan 22;13:479-492. •Cancer Cell Int. 2021 Jun 5;21(1):291. •J Cell Mol Med. 2019 Apr;23(4):2399-2409. •FASEB J. 2021 Apr;35(4):e21457. •FASEB J. 2019 Apr;33(4):5520-5534. •Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):3911-3919. •Vet Microbiol. 2021, 109177. •J Radiat Res. 2017 Jul 1;58(4):474-486. •Precision Clinical Medicine. pbab022. •bioRxiv. May 20, 2021.
纯度及产品资料	98%

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