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抑制剂/激活剂

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凋亡与自噬

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Ferrostatin-1

Ferrostatin-1 是一种有效的、选择性的 ferroptosis 抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。具有抗真菌活性。

货号：
TK0113
规格：

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	347174-05-4
生物活性	Ferrostatin-1, a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity.
分子式	C15H22N2O2
分子量	262.35
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light
溶解性数据	DMSO : 125 mg/mL (476.46 mM; Need ultrasonic)
体内研究	Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction . Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI). Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis.
体外研究	Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices. Fer-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability.
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纯度及产品资料	98%

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