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抑制剂/激活剂

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凋亡与自噬

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Streptozocin 链脲佐菌素; Streptozotocin; U 9889

Streptozocin 是一种抗生素，可使 DNA 甲基化 (DNA-methylating) 。Streptozocin 引起肝脏，肾脏及胰腺 DNA 甲基化，但脑 DNA 中没有甲基化。

货号：
TK0111
规格：

5mg

10mg

25mg

100mg
价格：
￥0.00

产品参数

CAS No.	18883-66-4
生物活性	Streptozocin is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA.
分子式	C8H15N3O7
分子量	265.22
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light, stored under nitrogen
溶解性数据	DMSO : 250 mg/mL (942.61 mM; Need ultrasonic) H2O : 113.3 mg/mL (427.19 mM; Need ultrasonic and warming)
体内研究	Streptozocin (STZ)-injected mice show tendency to have lower body weight than that observed in animals injected with ALX. Streptozocin -injected mice have significantly fewer splenocytes (22.2±3.2×10; n=10) compared to mice injected with ALX (60.7±4.3×10; n=15; p=0.01).
体外研究	Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). ALX appeares not to be toxic for the studied cell lines with estimated IC50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. The IC50 values of Streptozocin are 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells, respectively. Results also show that the murine leukemic cells are more resistant to Streptozocin and ALX cytotoxicity than human leukemic cells.
文献	•Nat Biomed Eng. 2021 Jan;5(1):53-63. •Nat Biomed Eng. 2020 May;4(5):507-517. •Sci Transl Med. 2020 Jul 1;12(550):eaba6676. •Clin Transl Med. 2021 Apr;11(4):e387. •Biomacromolecules. 2021 Jul 27. •Int J Biol Sci. 2021 Oct 11;17(15):4207-4222. •Food Funct. 5th October 2021. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193. •J Pharm Pharmacol. 2021 Aug 12;rgab112. •J Pharm Pharmacol. 2020 Dec;72(12):1798-1811. •Stanford University. Department of Materials Science and Engineering. 2021 Nov. •Comp Clin Pathol. 2020 Oct 28. •BMC Complement Med Ther. 2020 Oct 23;20(1):321. •Heliyon. 2020 May 21;6(5):e03989. •bioRxiv. 2020 Feb. •Chinese Journal of Clinical Pharmacoly and Therapeutics. 2017, 22(8): 846-851.
纯度及产品资料	98%

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